Every morning after applying your serum, skim off the foam at the surface of the cream. For optimal effectiveness and to maximise skin oxygenation: Do not heat the cream in your hands. Skim off the foam, apply four dabs of cream on the face and rub in using light effleurage gestures. If possible, skim off and apply the cream using the small brush provided. For a complete oxygenating program, use Prime Regenera I as your night cream.